The Yendi Diocese was created on 16th March 1999 out of the Archdiocese of Tamale as the third diocese in the Northern Region of Ghana. Most Rev. Vincent Sowah Boi-Nai, SVD was appointed and subsequently installed as the first Bishop on 10th July 1999.

The Cathedral is the Yendi Parish Church, dedicated to Our Lady of Lourdes. It is located at the Eastern part of the region. It covers about 35% of the total landmass of the Northern Region.